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phenobarbital increases toxicity of ifosfamide by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check. CYP3A4 inducers may perhaps raise the metabolism of ifosfamide to its Lively alkylating metabolites.If indications of withdrawal happen on the initial working day of remedy, a loading dose of 100 to 200 mg of phenobarbital m